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1a,25-(OH)2D3 Regulates 25-Hydroxyvitamin D3 24R-Hydroxylase Activity in Growth Zone Costochondral Growth Plate Chondrocytes via Protein Kinase C

✍ Scribed by Z. Schwartz; H.A. Pedrozo; V.L. Sylvia; R. Gomez; D.D. Dean; B.D. Boyan

Book ID
105912831
Publisher
Springer
Year
2001
Tongue
English
Weight
370 KB
Volume
69
Category
Article
ISSN
1432-0827

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## Abstract Phospholipase A~2~ (PLA~2~) is pivotal in the rapid membrane‐mediated actions of 1,25‐dihydroxyvitamin D3 [1α,25(OH)~2~D~3~]. Microarray analysis indicated that PLA~2~ activating protein (PLAA) mRNA is upregulated 6‐fold before rat growth plate cells exhibit 1α,25(OH)~2~D~3~‐dependent p

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Recent studies have shown that 24R,25-(OH) 2 D 3 mediates its effects on growth plate chondrocytes via membrane receptors. This study examined the roles of phospholipase A 2 (PLA 2 ) and cyclooxygenase (Cox) in the mechanism of action of 24R,25-(OH) 2 D 3 in resting zone chondrocytes in order to det