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Melittin, a Metabostatic Peptide Inhibiting Gs Activity

✍ Scribed by Nobuyuki Fukushima; Masayuki Kohno; Takeshi Kato; Susumu Kawamoto; Kenji Okuda; Yoshimi Misu; Hiroshi Ueda


Book ID
117409183
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
569 KB
Volume
19
Category
Article
ISSN
0196-9781

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A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t