Antianaerobic activity of a cecropin-melittin peptide
✍ Scribed by Charlotta Edlund; Maria Hedberg; Åke Engström; Jan-Ingmar Flock; David Wade
- Book ID
- 111107810
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 351 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1198-743X
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## Abstract Synthesis and conformational studies of a cecropin–melittin hybrid pentadecapeptide CA(1–7)MEL(2–9), and its three α, β‐dehydrophenylalanine (ΔPhe) containing analogs in water‐TFE mixtures are described. ΔPhe is placed at strategic positions in order to preserve the amphipathicity of th
A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t