𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of succinylation on the membrane activity and conformation of a short cecropin A-melittin hybrid peptide

✍ Scribed by Imma Fernández; Josep Ubach; Francesca Reig; David Andreu; Miquel Pons

Publisher
Wiley (John Wiley & Sons)
Year
1994
Tongue
English
Weight
597 KB
Volume
34
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of this peptide on liposome permeability. Conformational analysis of the parent peptide and its succinyl derivative by CD and nmr indicates that both peptides form amphipathic a-helices in the presence of hexafluoro-2-propanol, but only the unmodified peptide acquires a relevant level of a-helical conformation in the presence of liposomes.

📜 SIMILAR VOLUMES

ChemInform Abstract: Influences of Hinge
ChemInform Abstract: Influences of Hinge Region of a Synthetic Antimicrobial Peptide, Cecropin A(1—13)-Melittin(1—13) Hybrid on Antibiotic Activity.
✍ Song Yub Shin; Joo Hyun Kang; Dong Gun Lee; So Yun Jang; Moo Yeol Seo; Kil Lyong 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 26 KB

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Effect of membrane mimicking environment
Effect of membrane mimicking environment on the conformation of a pore-forming (xSxG)6 peptide
✍ Jyothi Thundimadathil; Roger W. Roeske; Lili Guo 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 387 KB

## Abstract The mechanism of membrane interaction by β‐sheet peptides is important to understand fundamental principles of folding of β‐barrel proteins and various β‐amyloid proteins. Here, we examined the conformational characteristics of a porin‐like channel forming (__x__S__x__G)~6~ peptide in s

The effect of tethered polymers on the c
The effect of tethered polymers on the conformation of a lipid membrane
✍ Tatiana M. Birshtein; Ekaterina B. Zhulina 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

## Abstract We consider the effect of tethered macromolecules on the stability of the flat conformation of a lipid bilayer in a dense brush regime when anchored chains are significantly overlapped. On the basis of a scaling approach we have shown that redistribution of polymer chains from inner to

Effect of oxygen gradients on the activi
Effect of oxygen gradients on the activity and microbial community structure of a nitrifying, membrane-aerated biofilm
✍ Leon S. Downing; Robert Nerenberg 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB 👁 2 views

## Abstract Shortcut nitrogen removal, that is, removal via formation and reduction of nitrite rather than nitrate, has been observed in membrane‐aerated biofilms (MABs), but the extent, the controlling factors, and the kinetics of nitrite formation in MABs are poorly understood. We used a special