A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t
Conformation and Self-Association of a Hybrid Peptide of Cecropin A and Melittin with Improved Antibiotic Activity
✍ Scribed by Imma Fernández; Josep Ubach; Monika Fuxreiter; José Manuel Andreu; David Andreu; Miquel Pons
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 940 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0947-6539
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
We have synthesized by solution-phase methods two analogues of the 11-residue lipopeptaibol antibiotic trichogin GA IV in which the N-terminal n-octanoyl group is replaced either by an N-acetylated 2-amino-2-methyl-L-undecanoic acid or by an N-acetylated h-aminoisobutyric acid. CD, FTIR absorption,