A 15-residue hybrid peptide ( KWKLFKKIGAVLKVL-amide) incorporating partial sequences of cecropin A and melittin causes the release of carboxyfluoresceine encapsulated in phosphatidylcholine liposomes. Succinylation of the amino groups in the N-terminus and lysine side chains inhibits the effect of t
Design, Recombinant Expression, and Antibacterial Activity of the Cecropins–Melittin Hybrid Antimicrobial Peptides
✍ Scribed by Yu Cao; Rong Qing Yu; Yi Liu; Huo Xiang Zhou; Ling Ling Song; Yi Cao; Dai Rong Qiao
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 390 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0343-8651
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## Abstract We have __de novo__ designed four antimicrobial peptides AMP‐A/B/C/D, the 51‐residues peptides, which are based on the conserved sequence of cecropin. In the present study, the four peptides were chemically synthesized and their activities assayed. Their secondary structure, amphipathic