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Melittin Binds to Secretory Phospholipase A2and Inhibits Its Enzymatic Activity

✍ Scribed by Shamsher S. Saini; Johnny W. Peterson; Ashok K. Chopra

Book ID
115580862
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
137 KB
Volume
238
Category
Article
ISSN
0006-291X

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Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi