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Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes

✍ Scribed by Reid, A. B.

Book ID
125444500
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2004
Tongue
English
Weight
366 KB
Volume
312
Category
Article
ISSN
0022-3565

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Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c