## Abstract Ammonia is a toxin that has been strongly implicated in the pathogenesis of hepatic encephalopathy (HE), and the astrocyte appears to be the principal target of ammonia toxicity. The specific neurochemical mechanisms underlying HE, however, remain elusive. One of the suggested mechanism
Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes
โ Scribed by K.V. Rama Rao; A.R. Jayakumar; M.D. Norenberg
- Book ID
- 116764653
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 316 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0197-0186
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๐ SIMILAR VOLUMES
Ammonia is the principal neurotoxin implicated in the pathogenesis of hepatic encephalopathy, and astrocytes are the neural cells predominantly affected in this condition. Astrocyte swelling (cytotoxic edema) represents a critical component of the brain edema in acute form of hepatic encephalopathy
## Abstract Hepatic encephalopathy (HE) is a major neurological complication in patients with severe liver disease. While the pathogenesis of HE is unclear, elevated blood and brain ammonia levels are believed to be major etiological factors, and astrocytes appear to be the primary target of its to