The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytes
โ Scribed by Reddy, Pichili V B; Rama Rao, Kakulavarapu V; Norenberg, Michael D
- Book ID
- 109885239
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 821 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0023-6837
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The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and apoptotic neuronal cell death, despite the fact that it has not been previously identified in neurons. To study the mPT in hippocampal neurons, cultures were loaded with the mitochondrial dye JC-1 and observe