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237 Role of the mitochondrial permeability transition in acetaminophen-induced necrotic and apoptotic cell death to cultured mouse hepatocytes

โœ Scribed by Kazuyoshi Kon; Jae-Sung Kim; Elizabeth Doyal; John J. LeMasters


Book ID
119530146
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
132 KB
Volume
38
Category
Article
ISSN
0270-9139

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Mitochondrial permeability transition in
โœ Kazuyoshi Kon; Jae-Sung Kim; Hartmut Jaeschke; John J. Lemasters ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 344 KB

Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c