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Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes

✍ Scribed by Jae-Sung Kim; Ting Qian; John J. Lemasters

Book ID
119756922
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
259 KB
Volume
124
Category
Article
ISSN
0016-5085

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✍ Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 356 KB

Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc