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Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

✍ Scribed by Kazuyoshi Kon; Jae-Sung Kim; Hartmut Jaeschke; John J. Lemasters

Book ID
111700333
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
344 KB
Volume
40
Category
Article
ISSN
0270-9139

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πŸ“œ SIMILAR VOLUMES

Mitochondrial permeability transition in
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes
✍ Kazuyoshi Kon; Jae-Sung Kim; Hartmut Jaeschke; John J. Lemasters πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 344 KB

Acetaminophen overdose causes massive hepatic failure via mechanisms involving glutathione depletion, oxidative stress, and mitochondrial dysfunction. The ultimate target of acetaminophen causing cell death remains uncertain, and the role of apoptosis in acetaminophen-induced cell killing is still c