Mechanism of action of cyclosporin?
โ Scribed by Helgi Valdimarsson
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 128 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
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๐ SIMILAR VOLUMES
We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of Tcells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of a@ TcR/CD3 complexes and a mature phenotype define
Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions