Mechanisms of Methotrexate Action in Rhe
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Gary S. Firestein; Mary M. Paine; David L. Boyle
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Article
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1994
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John Wiley and Sons
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English
β 852 KB
To measure the effect of methotrexate (MTX) treatment in rheumatoid arthritis (RA) on the expression of synovial collagenase, stromelysin, and tissue inhibitor of metalloproteinase 1 (TIMP-1) gene expression in a prospective study. Methods. Serial percutaneous synovial biopsies (pretreatment and af