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Mechanism of action of cyclosporin A

โœ Scribed by David White


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
35 KB
Volume
29
Category
Article
ISSN
0165-2478

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We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of Tcells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of a@ TcR/CD3 complexes and a mature phenotype define

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The introduction of cyclosporine (CyA) as a pharmacological agent has resulted not only in a dramatic improvement in the clinical management of transplant recipients but also in a better understanding of the molecular basis of the immune response, especially T cell function. Knowledge of the mechani