Mechanism of action of cyclosporin A
โ Scribed by David White
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 35 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0165-2478
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of Tcells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of a@ TcR/CD3 complexes and a mature phenotype define
Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions
The introduction of cyclosporine (CyA) as a pharmacological agent has resulted not only in a dramatic improvement in the clinical management of transplant recipients but also in a better understanding of the molecular basis of the immune response, especially T cell function. Knowledge of the mechani