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Inhibition of T cell developmemt in thymic organ culture: Implications for the mechanism of action of cyclosporin A

✍ Scribed by Richard M. Siegel; Katsuyuki Yui; Drew E. Tenenholz; Ralph Kubo; Mark I. Greene

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 834 KB
Volume: 20
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830200407

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✦ Synopsis

We have examined the effects of the immunosuppressive drug cyclosporin A (CsA) on the phenotypic maturation of Tcells in thymic organ cultures begun at day 16 of gestation. CsA specifically inhibited the generation of cells expressing high levels of a@ TcR/CD3 complexes and a mature phenotype defined by CD4 and CD8 surface markers. Adding interleukin (IL) lfi, IL 2 or IL 4 failed to reverse the effects of CsA, and major histocompatibility complex class I1 expression in the thymic medulla was preserved. Possible mechanisms of CsA-mediated inhibition of T cell development are discussed. ~ ~~~ * These studies were supported by the Lucille Markey Charitable Trust and grants from the N.I.H., N.E.I. and N.C.I. to M.I.G. Special Fellow of the Leukemia Society of America.

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