✦ LIBER ✦

T cell requirements for the expression of the lipopolysaccharide adjuvant effect in vivo: evidence for a T cell-dependent and a T cell-independent mode of action

✍ Scribed by Dolly B. Ness; S. Smith; J. A. Talcott; F. C. Grumet

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 537 KB
Volume: 6
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830060911

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✦ Synopsis

Abstract

The in vivo adjuvant effect of lipopolysaccharide (LPS) in mice was investigated with the soluble synthetic polypeptide antigen (T, G)‐A–L, the antibody response to which is determined by the Ir‐1A gene. With this specific antigen it can be demonstrated that the LPS adjuvant effect has the following modes of action: a) a T cell‐independent enhancement of primary and secondary IgM antibody response; b) a T cell‐dependent enhancement of IgG secondary antibody response; and c) a T cell‐dependent induction of switchover from IgM to IgG antibody in some strains of Ir‐1A low responders. Although T cells are necessary for some aspects of the adjuvant effect, these data do not distinguish between a mechanism involving a direct interaction between LPS and T cells or a direct interaction of LPS and B cells with a general requirement for T cells for expression of IgG antibody.

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