Mean residence time: Some further consideration
โ Scribed by Paul S. Collier
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 331 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
โฆ Synopsis
The correct use of probability distribution functions is described for the determination of mean residence time (MRT) of drug molecules in the body and is illustrated for two possible two compartment body models. A new method for estimating (MRT) is described, based on the area under the curve measurement for the decay of drug from steady state.
๐ SIMILAR VOLUMES
## KEY WORDS Mean residence time MRT Moments Statistical moments Mean absorption time MAT Pharmacokinetics Pharmacodynamics Biopharmaceutic Mean residence time has been the subject of much research and discussion in recent pharmacokinetic literature. Unfortunately confusion can result from the def
A new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non-linear systems. Some practical advantages which follow from the new definition are discussed. Procedur