Definition of mean residence times in pharmacokinetics
β Scribed by David J. Cutler
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 456 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0142-2782
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β¦ Synopsis
A new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non-linear systems. Some practical advantages which follow from the new definition are discussed. Procedures for using urinary excretion data in mean residence time estimation are discussed.
π SIMILAR VOLUMES
## KEY WORDS Mean residence time MRT Moments Statistical moments Mean absorption time MAT Pharmacokinetics Pharmacodynamics Biopharmaceutic Mean residence time has been the subject of much research and discussion in recent pharmacokinetic literature. Unfortunately confusion can result from the def
A method for calculating the mean residence times of metabolites in the body, systemic circulation, and peripheral tissue is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration versus time curves of the metabolite and its precursor. The method is applicable
The relationship between the mean residence time after oral dosing or any other non-instantaneous mode of administration (MRT,,) was explored by a series of computer simultations. MRT,, was calculated from the ratio of AUMC to A U C (where A U C and A U M C are the zeroth and first statistical momen
## Abstract Modeling and simulation at different scales were used to study mass transport and residence times of particles in nanostructured membranes with uniform cylindrical pores of 10β150 nm diameter and up to 5 ΞΌm long. Analytical equations of the possible massβtransport mechanisms inside the