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The relationship between drug input and mean residence time in the body

โœ Scribed by Meir Bialer; Zee M. Look; B. Michael Silber; Avraham Yacobi

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
316 KB
Volume
7
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The relationship between the mean residence time after oral dosing or any other non-instantaneous mode of administration (MRT,,) was explored by a series of computer simultations. MRT,, was calculated from the ratio of AUMC to A U C (where A U C and A U M C are the zeroth and first statistical moments, respectively, of the drug concentration-time curve). A continuous linear relationship between MRT,, and lik, or llko was observed. In the 'flip-flop' case where k , < K (where K is the elimination rate constant), the extrapolation from t* to infinity (where t* is the last observed plasma concentration) should be done using k , instead of K . If K is used, underestimated values of MRT,, will be obtained. The findings from this investigation have practical application in the design and pharmacokinetic evaluation of novel sustained-release dosage forms.

KEY WORDS Mean residence rime Oral administration Absorption kinetics Drug inputfirst and zero order absorption

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