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Mammalian Cells Defective in DNA Mismatch Correction

✍ Scribed by P. BRANCH; G. AQUILINA; P. HESS; M. BIGNAMI; P. KARRAN

Book ID
119871226
Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
176 KB
Volume
726
Category
Article
ISSN
0890-6564

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Mismatch repair in mammalian cells
Mismatch repair in mammalian cells
✍ Louise A. Heywood; Julian F. Burke πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 605 KB

A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100-1000 fold increase in mutation frequency observed in cells deficient in this repair system"'. Mismatches can arise as a consequence