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Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

โœ Scribed by Branch, P.; Aquilina, G.; Bignami, M.; Karran, P.


Book ID
109783887
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
399 KB
Volume
362
Category
Article
ISSN
0028-0836

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Together with tolerance to killing induced by methylating agents, loss of mismatch repair (MMR) has previously been found to be associated with hypersensitivity to the DNAcross-linking agent 1-(2-chloroethyl)-3-cyclohexyl-nitrosourea(CCNU) in several human tumor cell lines (Aquilina et al., 1998). H