✦ LIBER ✦

Mismatch repair in mammalian cells

✍ Scribed by Louise A. Heywood; Julian F. Burke

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 605 KB
Volume: 12
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950121004

No coin nor oath required. For personal study only.

✦ Synopsis

A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100-1000 fold increase in mutation frequency observed in cells deficient in this repair system"'. Mismatches can arise as a consequence of recombination, errors in replication and as a result of spontaneous chemical deamination, the latter process resulting in an estimated twelve T:G mismatches per genome per day in mammalian celld2'. Recent studies, discussed here, provide evidence for the existence of specific mismatch repair systems in mammalian and human cells.

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