DNA mismatch repair defects: role in colorectal carcinogenesis
✍ Scribed by Sandrine Jacob; Françoise Praz
- Book ID
- 117456702
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 309 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0300-9084
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Colorectal cancer is the second commonest malignancy in the western world, accounting for 20 000 deaths in the U.K. per year. Over the last 10 years, great strides have been made in our understanding of the molecular controls governing the transition from normal mucosa, through adenoma, and finally
Most colorectal adenomas and carcinomas arise in the setting of chromosomal instability and progressive loss of heterozygosity. Approximately 15-20% of colorectal neoplasms arise through a distinct genetic pathway characterized by microsatellite instability (MSI) and frequent loss of expression of o