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Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair

✍ Scribed by Carmela Ciotta; Sabrina Ceccotti; Gabriele Aquilina; Odile Humbert; Fabio Palombo; Josef Jiricny; Margherita Bignami


Book ID
115628375
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
420 KB
Volume
276
Category
Article
ISSN
0022-2836

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DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at