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Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level

โœ Scribed by Claij, Nanna; te Riele, Hein

Book ID
110066591
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
160 KB
Volume
21
Category
Article
ISSN
0950-9232

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5