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Lymphocyte activation: T-cell regulation by CTLA-4

✍ Scribed by Peter S Linsley; Pierre Golstein


Book ID
114318878
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
65 KB
Volume
6
Category
Article
ISSN
0960-9822

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The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD

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## Abstract CD8^+^ T lymphocytes are required for effective host defense against pathogens and also for mediating effector responses against uncontrolled proliferating self‐tissues. In this study, we determine that individual CD8^+^ T cells are tightly controlled in their effector functions by CD15