## Abstract ## BACKGROUND: Polymorphisms in the cytotoxic T‐lymphocyte antigen 4 (__CTLA‐4__) gene have been implicated in susceptibility to cancer, but the many published studies have reported inconclusive results. The objective of the current study was to conduct a meta‐analysis investigating th
✦ LIBER ✦
A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1 +49) alters T-cell activation
✍ Scribed by Mathias Mäurer, Silke Loserth, Annette Kolb-Mäurer, Anke Ponath, Stefan Wiese, Niels Kruse, Peter Rieckmann
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 261 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0093-7711
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The CTLA-4 gene encodes a T-cell receptor that is involved in the regulation of T-cell activation. Recent studies have demonstrated an association of a microsatellite polymorphism [variant lengths of a dinucleotide (AT)n repeat] lying in exon 3 of the CTLA-4 gene, specifically a 106-bp allele, with
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