The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD
Dexamethasone enhances CTLA-4 expression during T cell activation
β Scribed by M. Xia; J. Gasser; U. Feige
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 351 KB
- Volume
- 55
- Category
- Article
- ISSN
- 1420-682X
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T-ccl1 actlvatkm" it was suggested that CTLA-4 may be able to deliver a signal that synergizes with that delivcmd by CD28.
## Abstract The importance of glycoprotein sialic acid levels is well known, as increased levels have been shown to increase in vivo serum halfβlife profiles. Here we demonstrate for the first time that dexamethasone (DEX) was capable of improving the sialylation of a CTLA4βIg fusion protein produc
## Abstract The differentiation and activation of T cells are critically modulated by MAP kinases, which are in turn feedβback regulated by dualβspecificity phosphatases (DUSPs) to determine the duration and magnitude of MAP kinase activation. DUSP4 (also known as MKP2) is a MAP kinaseβinduced DUSP