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Is CTLA-4 a negative regulator for T-cell activation?

✍ Scribed by Yang Liu

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
238 KB
Volume
18
Category
Article
ISSN
0167-5699

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✦ Synopsis

T-ccl1 actlvatkm" it was suggested that CTLA-4 may be able to deliver a signal that synergizes with that delivcmd by CD28.

πŸ“œ SIMILAR VOLUMES

CTLA-4 and T cell activation
CTLA-4 and T cell activation
✍ Mariette A Oosterwegel; Rebecca J Greenwald; Didier A Mandelbrot; Robert B Lorsb πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 English βš– 864 KB

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD