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CTLA-4 and T cell activation

✍ Scribed by Mariette A Oosterwegel; Rebecca J Greenwald; Didier A Mandelbrot; Robert B Lorsbach; Arlene H Sharpe

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 864 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)80047-8

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✦ Synopsis

The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate that CTLA-4 not only counterbalances CD28 signals but also can inhibit T cell responses independently of CD28. Recent work has also revealed a role for CTLA-4 in regulating Thl /lhP differentiation. Manipulation of CTLA-4 in animal models of autoimmunity has shown that CTlA-4 regulates both the initiation and the progression of autoimmune diseases.

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