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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

โœ Scribed by Sharpless, Norman E.; Bardeesy, Nabeel; Lee, Kee-Ho; Carrasco, Daniel; Castrillon, Diego H.; Aguirre, Andrew J.; Wu, Emily A.; Horner, James W.; DePinho, Ronald A.


Book ID
109775812
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
243 KB
Volume
413
Category
Article
ISSN
0028-0836

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Cdkn2a encodes functional variation of p
โœ Christopher R. Herzog; Seong Noh; Laura E. Lantry; Kuan-Liang Guan; Ming You ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 107 KB ๐Ÿ‘ 1 views

The cyclin-dependent kinase inhibitor 2a (Cdkn2a) locus encodes two distinct tumor suppressors, p16INK4a and p19ARF, whose functions interrelate in the regulation of cell proliferation as key components of the retinoblastoma and p53 pathways, respectively. In many types of cancer, alterations of Cdk