Immortalization of mouse myogenic cells can occur without loss of p16INK4a, p19ARF, or p53 and is accelerated by inactivation of Bax

Resistance of primary cultured mouse hep

Resistance of primary cultured mouse hepatic tumor cells to cellular senescence despite expression of p16Ink4a, p19Arf, p53, and p21Waf1/Cip1

✍ Masahiko Obata; Emi Imamura; Yukinori Yoshida; Junichi Goto; Kan Kishibe; Atsumi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB

Primary cultured mouse hepatic cells become senescent within a short period, although rare cells form colonies from which continuously proliferating cell lines can be established. In contrast, hepatic tumor (HT) cells show little senescence and higher colony-forming capacity. To assess this differen