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p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice

โœ Scribed by Shank-Calvo, J A; Draheim, K; Bhasin, M; Kelliher, M A


Book ID
110070349
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
368 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract TGFฮฒ1 acts as a potent negative regulator of the cell cycle and tumor suppressor in part through induction of cyclin dependent kinase inhibitors p15^ink4b^, p21, and p57. We previously showed that primary mouse epidermal keratinocytes (MEK) expressing a vโ€__ras__^Ha^ oncogene undergo hy