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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

✍ Scribed by Krimpenfort, Paul; Quon, Kim C.; Mooi, Wolter J.; Loonstra, Ate; Berns, Anton


Book ID
109775811
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
298 KB
Volume
413
Category
Article
ISSN
0028-0836

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## Abnormalities of the G 1 cell-cycle checkpoint are commonly reported in cancers at various anatomic sites. pRB, p16 INK4a and cyclin D1 are critical G 1 -checkpoint proteins responsible for maintaining the balance of cellular proliferation. We examined a series of 38 pediatric osteosarcomas for