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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

โœ Scribed by Zuo, Lin; Weger, John; Yang, Qingbei; Goldstein, Alisa M.; Tucker, Margaret A.; Walker, Graeme J.; Hayward, Nicholas; Dracopoli, Nicholas C.


Book ID
109914966
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
328 KB
Volume
12
Category
Article
ISSN
1061-4036

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Mutation analysis of two genes involved in melanoma susceptibility (CDKN2A/p16 INK4a and CDK4) was undertaken in 131 probands with a family history of melanoma. Screening of all three exons of CDKN2A and exon 2 of CDK4 by single-strand conformation polymorphism (SSCP) analysis and/or direct sequenci