Loss of heterozygosity at D3S2 locus of short arm of chromosome 3 in chronic myelogenous leukemia
β Scribed by Kimio Tanaka; Ahmed M. Mansoor; Chiharu Shigeta; Nobuo; Oguma; Nanao Kamada
- Book ID
- 119105571
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 337 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0165-4608
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## Loss of heterozygosity (LOH) on chromosomes 3p and 9p has been documented in a variety of malignancies, which suggests the presence of tumor suppressor gene loci on these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human chromosomes.
## Abstract Cytogenetic analysis of mesothelioma cell lines and solid tumors has documented nonβrandom chromosomal abnormalities on the short arm of chromosome 3 from 3p 14 to 3p25. We therefore examined nine mesothelioma cell lines, their corresponding tumors, and 15 additional mesothelioma tumors
## Abstract A majority of renalβcell tumours retain heterozygosity at the short arm of chromosome 3. To investigate possible histopathological differences between tumours with and without such losses, we compared loss of heterozygosity data from 51 tumours with 1 histological and 2 different cytolo