We have examined I 7 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte D N A from the same patients. Ten polymorphic microsatellite markers were used between 3p I 3 and 3p26. Allelic IOU was observed in
Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma
โ Scribed by Dolly P. Huang; Kwok-Wai Lo; Peter H.K. Choi; Angela Y.T. Ng; Shiu-Ying Tsao; Gary K.C. Yiu; Joseph C.K. Lee
- Book ID
- 119104819
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 477 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0165-4608
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The main objective of this study was to determine the precise frequency of chromosome 14q loss of heterozygosity in nasopharyngeal carcinomas and to define its minimal deletion regions. Thirty-nine tumors were selected for PCRbased deletion mapping using 19 microsatellite polymorphic markers spannin
## Loss of heterozygosity (LOH) on chromosomes 3p and 9p has been documented in a variety of malignancies, which suggests the presence of tumor suppressor gene loci on these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human chromosomes.