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Loss of heterozygosity of the short arm of chromosomes 3 and 9 in oral cancer

✍ Scribed by Chandramohan S. Ishwad; Robert E. Ferrell; Karen M. Rossie; Billy N. Appel; Jonas T. Johnson; Eugene N. Myers; John C. Law; S. Srivastava; Susanne M. Gollin

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 453 KB
Volume: 69
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960220)69:1<1::aid-ijc1>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

Loss of heterozygosity (LOH) on chromosomes 3p and 9p has

been documented in a variety of malignancies, which suggests the presence of tumor suppressor gene loci on these chromosomes. We have studied 77 oral carcinomas for LOH using 16 microsatellite markers distributed over 5 human chromosomes.

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