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Linkage analysis and loss of heterozygosity for chromosome arm 1p in familial breast cancer

✍ Scribed by Robert C. Millikan; Sue A. Ingles; Anh T. Diep; Shanyan Xue; Nianmin Zhou; Barbara D. Florentine; Robert S. Sparkes; Robert W. Haile

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
129 KB
Volume
25
Category
Article
ISSN
1045-2257

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✦ Synopsis

We conducted linkage analysis of 64 multiple-case families with early-onset bilateral breast cancer using DNA markers on chromosome band 1p36. Evidence against tight linkage was obtained using a dominant model for transmission (summary LOD scores at recombination fraction Ο­ 0.000001 were -4.71 for D1S160 and -2.70 for D1S170). Similar results were obtained after excluding 20 families that were potentially attributable to BRCA1 or BRCA2. We also investigated loss of heterozygosity for a panel of markers on chromosome arm 1p using breast tumors from affected family members. The most common regions of allele loss were 1p36 (32% for D1S160, 35% for D1S243) and 1p32 (51% for MYCL). The frequency and location of 1p allele loss did not differ substantially from previous studies of sporadic breast cancer. We conclude that 1p36 probably does not contain a locus of susceptibility for a large proportion of breast cancer families, but a variety of loci on 1p may contribute to progression of familial and sporadic disease.

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