High incidence of derivative chromosome arm 9q deletions in Asian chronic myelogenous leukemia
β Scribed by Sim-Leng Tien; Christina Rudduck-Sivaswaren; Ping Lim; Elizabeth Lim; Daniel K. H. Lie; Patrick HC Tan; Ann S. G. Lee
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 50 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1045-2257
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## Abstract ## BACKGROUND: Deletions of derivative chromosome 9 are a poor prognostic factor in patients with chronic myeloid leukemia (CML) treated with hydroxyurea, interferon, or stem cell transplantation. Imatinib may overcome the adverse prognostic impact of deletions of derivative chromosome
## Abstract Fluorescence in situ hybridization for the __BCR__/__ABL__ rearrangement in 138 bone marrow specimens from 59 Philadelphia^+^ (Ph^+^) chronic myelogenous leukemia (CML) patients, 35 Ph^+^ acute lymphoblastic leukemia (ALL) patients, and 57 Ph^β^ ALL patients was used. Sixteen (27.1%) of