Genesis of derivative chromosome 9 deletions in chronic myeloid leukemia
β Scribed by Alistair G. Reid; Ellie P. Nacheva
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 46 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1045-2257
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## Abstract ## BACKGROUND: Deletions of derivative chromosome 9 are a poor prognostic factor in patients with chronic myeloid leukemia (CML) treated with hydroxyurea, interferon, or stem cell transplantation. Imatinib may overcome the adverse prognostic impact of deletions of derivative chromosome
A reciprocal translocation, t( I022)(q2Z;q I I), resulting in a masked Ph chromosome was identified in a patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for the ABL probe, both of them hybridized to chromosome 9, were demon
We encountered a 67-year-old female with chronic neutrophilic leukemia (CNL). Cytogenetic study showed she had a deletion in the long arm of chromosome 20. This finding indicates that CNL, in this case, is a clonal disorder. Most CNL patients have normal karyotypes, and only four patients with cytog