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BCR/ABL fusion located on chromosome 9 in chronic myeloid leukemia with a masked Ph chromosome

✍ Scribed by Anwar N. Mohamed; F. Koppitch; M. Varterasian; C. Karanes; Kai-Ling Yao; F. H. Sarkar

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
394 KB
Volume
13
Category
Article
ISSN
1045-2257

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✦ Synopsis

A reciprocal translocation, t( I022)(q2Z;q I I), resulting in a masked Ph chromosome was identified in a patient diagnosed with chronic myeloid leukemia (CML). Both homologs of chromosome 9 were of the normal pattern. Two signals for the ABL probe, both of them hybridized to chromosome 9, were demonstrated via fluorescence in situ hybridization (FISH). Furthermore, cohybridization with two differently labeled BCRIABL translocation DNA probes indicated a BCWABL fusion apparently located on 9q34. Molecular studies revealed a rearrangement of the BCR region and expression of a chimeric BCRIABL mRNA of CML configuration. These findings indicate that the BCWABL fusion resulted from an unusual relocation of the BCR gene from its normal position on 22ql I to 9q34 adjacent to the ABL gene. Genes Chromosorn Cancer 13:133-137 (1995)

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