Location of the BCR-ABL fusion gene on the 9q34 band in two cases of Ph-positive chronic myeloid leukemia
✍ Scribed by Joan Aurich; Nicole Dastugue; Eliane Duchayne; Daniel Schlaifer; Françoise Rigal-Huguet; M. Rosa Caballin
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 139 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR-ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;q11), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretation of cytogenetic, FISH, and molecular data. The mechanisms of the two rearrangements are presented. It is suggested that the insertion has occurred in a single event in the patient with ins(9;22). In the patient with t(9;22), both a translocation and an insertion, occurring either sequentially or simultaneously, can account for the location of the BCR-ABL fusion gene on the derivative 9. A possible poor prognostic impact of this aberrant location of the BCR-ABL is also suggested by the clinical data reported in such patients.