One hundred patients with Ph'-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph' chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bonemarrow cells. Our st
DNA measurements of chromosomes 9 and 22 of six patients with t(9;22) and chronic myeloid leukemia
โ Scribed by J. P. M. Geraedts; M. Van der Ploeg
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 411 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0196-4763
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W e performed molecular studies to resolve the status of BCR and ABL in the bone marrow cells of a CML patient with a Ph chromosome resulting from a complex translocation involving chromosomes 9, 15, and 22. D N A digestion with BomHI, Hindlll, and Bglll, followed by hybridization to a bcr-specific
## Abstract Chronic myeloid leukemia (CML) is characterized by the presence of a t(9;22)(q34;q11.2), which leads to the wellโknown BCRโABL1 fusion protein. We describe a patient who was diagnosed clinically with a typical CML but on cytogenetic analysis was found to have a t(9;22)(p24;q11.2). Chrom