✦ LIBER ✦

Spatial relationship of chromosomes 9 and 22 at metaphase in patients with chronic myelogenous leukemia (CML)

✍ Scribed by Ram S. Verma; Samuel Thomas; Morton Coleman; Richard T. Silver

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 426 KB
Volume: 41
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910410609

No coin nor oath required. For personal study only.

✦ Synopsis

One hundred patients with Ph'-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph' chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bonemarrow cells. Our study suggests that the rearranged chromosomes, i.e., Ph' and t(9;22), are closer together than their normal homologues. This impression is based on extensive statistical analysis. The intimate relationship may be due to the fact that they carry reciprocal genetic material responsible for a power of attraction between them. Alternatively, it is tempting to hypothesize that there may be a DNA sequence homology in the bands of chromosomes 9q and 22q involved in the reciprocal translocation perpetuating this relationship in subsequently generating cells during mitotic cell divisions. Furthermore, c-abl and bcr genes might play some role in maintaininp: the spatial relationship.

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