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Loss of heterozygosity on the short arm of chromosome 3 in mesothelioma cell lines and solid tumors

✍ Scribed by Martha A. Zeiger; James R. Gnarra; Berton Zbar; W. Marston Linehan; Harvey I. Pass

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 747 KB
Volume: 11
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870110104

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cytogenetic analysis of mesothelioma cell lines and solid tumors has documented non‐random chromosomal abnormalities on the short arm of chromosome 3 from 3p 14 to 3p25. We therefore examined nine mesothelioma cell lines, their corresponding tumors, and 15 additional mesothelioma tumors for loss of heterozygosity on 3p from 3p 13 to 3p25.5 by polymerase chain reaction and restriction fragment length polymorphism analysis at 8 loci: D3S3, D3S30, D3S6, D3S2, D3S32, D3FI5S2, THRB, and VHL Loss of heterozygosity was documented by loss of one of two alleles in the tumor DNA whose corresponding normal DNA was heterozygous and was documented in four of nine mesothelioma cell lines and six of 15 mesothelioma tumors or a total of 42% of the mesotheliomas evaluated. This study suggests the involvement of a gene on the short arm of chromosome 3 in the development of mesotheliomas.

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