Localization of BRCA1 Protein in Human Breast Cancer Cells
✍ Scribed by Monique Chambon; Philippe Nirdé; Michel Gleizes; Pascal Roger; Françoise Vignon
- Book ID
- 110435761
- Publisher
- Springer US
- Year
- 2003
- Tongue
- English
- Weight
- 556 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a four‐subunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogen‐dependent transcriptio
## Abstract BRCA1 is a multifunctional tumor‐suppressive protein. Many functional aspects of BRCA1 are not fully understood. We used a shRNA approach to probe the function of BRCA1 in human breast cancer cells. Knocking down BRCA1 expression by shRNA in the wild‐type BRCA1 human breast cancer MCF‐7