Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells
β Scribed by Kehn, K; Berro, R; Alhaj, A; Bottazzi, M E; Yeh, W-I; Klase, Z; Van Duyne, R; Fu, S; Kashanchi, F
- Book ID
- 110072316
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 389 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Cyclin D1 plays an important role in cell cycle progression. In breast cancer, Cyclin D1 expression is deregulated by several mechanisms. We previously showed that in breast cancer cells, overexpression of BRCA1βIRIS induces Cyclin D1 overexpression and increases cell proliferation. BRC
We have used immunohistochemical staining to assess the expression of cyclin D I in formalin-fixed sections of 345 breast carcinomas, dating back 20 years. Clinical follow-up data were available on all patients. Approximately 50% of the tumours showed excessive nuclear staining for cyclin DI as comp
## Abstract Cofactor of BRCA1 (COBRA1) is an integral component of the human negative elongation factor (NELF), a fourβsubunit protein complex that inhibits transcription elongation. Previous in vivo work indicates that COBRA1 and the rest of the NELF complex repress estrogenβdependent transcriptio